Cost-Efficient and Easy to Perform PCR-Based Assay to Identify Met Exon 14 Skipping in Formalin-Fixed Paraffin-Embedded (FFPE) Non-Small Cell Lung Cancer (NSCLC) Samples

Cost-Efficient and Easy to Perform PCR-Based Assay to Identify Met Exon 14 Skipping in Formalin-Fixed Paraffin-Embedded (FFPE) Non-Small Cell Lung Cancer (NSCLC) Samples

MET is a receptor tyrosine kinase (RTK) that plays important roles in carcinogenesis. Despite being frequently overexpressed in cancer, clinical responses to targeting this receptor have been limited. Recently novel splicing mutations involving the loss of exon 14 (called METex14 skipping) have emer...

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Bibliographic Details
Main Authors: Odharnaith O’Brien, Mark C. Wright, Cathal O’Brien, Orla Geoghegan, Niamh Leonard, Siobhan Nicholson, Sinéad Cuffe, Aurelie Fabre, Wolfram Jochum, Markus Joerger, Steven G. Gray, Stephen P. Finn
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Diagnostics
Subjects:
Met exon 14 skipping
diagnostic assay
PCR
next generation sequencing
RNA hybridisation
Online Access:http://www.mdpi.com/2075-4418/9/1/13

Internet

http://www.mdpi.com/2075-4418/9/1/13

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