KV11.1 Potassium Channel and the Na+/H+ Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells

KV11.1 Potassium Channel and the Na+/H+ Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells

Increasing evidence indicates that ion channels and transporters cooperate in regulating different aspects of tumor pathophysiology. In cancer cells, H+/HCO3- transporters usually invert the transmembrane pH gradient typically observed in non-neoplastic cells, which is thought to contribute to cance...

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Bibliographic Details
Main Authors: Jessica Iorio, Claudia Duranti, Tiziano Lottini, Elena Lastraioli, Giacomo Bagni, Andrea Becchetti, Annarosa Arcangeli
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
hERG1
integrins
Collagen I
beta 1 integrin subunit
cariporide
lateral motility
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00848/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00848/full

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