SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury, coronary circulation is a so far neglected target of cardioprotection. In this study, we investigated the molecular mechanisms underlying I/R injury to cardiac microcirculation. Using gene delivery, we ana...

Full description

Bibliographic Details
Main Authors: Ying Tan, David Mui, Sam Toan, Pingjun Zhu, Ruibing Li, Hao Zhou
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cardiac microvascular I/R injury
XO
ROS
SERCA
mitochondrial quality control
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302845

Internet

http://www.sciencedirect.com/science/article/pii/S2162253120302845

Similar Items