Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment

Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment

Abstract Background The APOBEC gene family of cytidine deaminases plays important roles in DNA repair and mRNA editing. In many cancers, APOBEC3B increases the mutation load, generating clusters of closely spaced, single-strand-specific DNA substitutions with a characteristic hypermutation signature...

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Bibliographic Details
Main Authors: Suleyman Vural, Richard Simon, Julia Krushkal
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Human Genomics
Subjects:
APOBEC mutagenesis
Cell line
Chemosensitivity
Gene expression
Online Access:http://link.springer.com/article/10.1186/s40246-018-0150-x

Internet

http://link.springer.com/article/10.1186/s40246-018-0150-x

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