20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1–AMP-activated protein kinase activation

20S-Protopanaxadiol, an aglycosylated ginsenoside metabolite, induces hepatic stellate cell apoptosis through liver kinase B1–AMP-activated protein kinase activation

Background: Previously, we reported that Korean Red Ginseng inhibited liver fibrosis in mice and reduced the expressions of fibrogenic genes in hepatic stellate cells (HSCs). The present study was undertaken to identify the major ginsenoside responsible for reducing the numbers of HSCs and the under...

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Bibliographic Details
Main Authors: Sang Mi Park, Eun Hye Jung, Jae Kwang Kim, Kyung Hwan Jegal, Chung A Park, Il Je Cho, Sang Chan Kim
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Ginseng Research
Subjects:
AMP-activated protein kinase (AMPK)
apoptosis
hepatic stellate cells (HSCs)
liver kinase B1 (LKB1)
20S-protopanaxadiol (PPD)
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845316301439

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http://www.sciencedirect.com/science/article/pii/S1226845316301439

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