3D-QSAR and Cell Wall Permeability of Antitubercular Nitroimidazoles against Mycobacterium tuberculosis

3D-QSAR and Cell Wall Permeability of Antitubercular Nitroimidazoles against Mycobacterium tuberculosis

Inhibitory activities of monocyclic nitroimidazoles against Mycobacterium tuberculosis (Mtb) deazaflavin-dependent nitroreductase (DDN) were modeled by using docking, pharmacophore alignment and comparative molecular similarity indices analysis (CoMSIA) methods. A statistically significant model obt...

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Bibliographic Details
Main Authors: Pyung Keun Myung, Sang-Ho Lee, Pilho Kim, Minsung Choi
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
antitubercular activity
monocyclic nitroimidazoles
Mycobacterium tuberculosis
3D-QSAR
cell wall permeability
Online Access:http://www.mdpi.com/1420-3049/18/11/13870

Internet

http://www.mdpi.com/1420-3049/18/11/13870

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