Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1-p300 Binding in Renal Cell Carcinoma

Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1-p300 Binding in Renal Cell Carcinoma

Angiogenesis and the expression of vascular endothelial growth factor (VEGF) are increased in renal cell carcinoma (RCC). Transglutaminase 2 (TGase 2), which promotes angiogenesis in endothelial cells during wound healing, is upregulated in RCC. Tumor angiogenesis involves three domains: cancer cell...

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Bibliographic Details
Main Authors: Seon-Hyeong Lee, Joon Hee Kang, Ji Sun Ha, Jae-Seon Lee, Su-Jin Oh, Hyun-Jung Choi, Jaewhan Song, Soo-Youl Kim
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
transglutaminase 2
angiogenesis
HIF-1, p53
renal cell carcinoma
Online Access:https://www.mdpi.com/1422-0067/21/14/5042

Internet

https://www.mdpi.com/1422-0067/21/14/5042

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