Cyclic RGD and <i>iso</i>DGR Integrin Ligands Containing <i>cis</i>-2-amino-1-cyclopentanecarboxylic (<i>cis</i>-β-ACPC) Scaffolds

Cyclic RGD and <i>iso</i>DGR Integrin Ligands Containing <i>cis</i>-2-amino-1-cyclopentanecarboxylic (<i>cis</i>-β-ACPC) Scaffolds

Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and <i>iso</i>-Asp-Gly- Arg (<i>iso</i>DGR) were actively investigated as inhibitors of tumor angiogenesis and directing unit in tumor-targeting drug conjugates. Reported herein is the synthesis, of two RG...

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Bibliographic Details
Main Authors: Silvia Panzeri, Daniela Arosio, Silvia Gazzola, Laura Belvisi, Monica Civera, Donatella Potenza, Francesca Vasile, Isabell Kemker, Thomas Ertl, Norbert Sewald, Oliver Reiser, Umberto Piarulli
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
peptidomimetics
integrin ligands
beta-amino acids
NMR conformational analysis
Online Access:https://www.mdpi.com/1420-3049/25/24/5966

Internet

https://www.mdpi.com/1420-3049/25/24/5966

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