Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue.

A popular method for studying the function of a given protein is to generate and characterize a suitable model deficient for its expression. For the prion protein (PrP), best known for its role in several invariably fatal neurodegenerative diseases, a natural choice, therefore, would be to undertake...

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Bibliographic Details
Main Authors: Mohadeseh Mehrabian, Dylan Brethour, Declan Williams, Hansen Wang, Hélène Arnould, Benoit Schneider, Gerold Schmitt-Ulms
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4915660?pdf=render