Reversible 26S Proteasome Disassembly upon Mitochondrial Stress

Reversible 26S Proteasome Disassembly upon Mitochondrial Stress

In eukaryotic cells, proteasomes exist primarily as 26S holoenzymes, the most efficient configuration for ubiquitinated protein degradation. Here, we show that acute oxidative stress caused by environmental insults or mitochondrial defects results in rapid disassembly of 26S proteasomes into intact...

Full description

Bibliographic Details
Main Authors: Nurit Livnat-Levanon, Éva Kevei, Oded Kleifeld, Daria Krutauz, Alexandra Segref, Teresa Rinaldi, Zoi Erpapazoglou, Mickael Cohen, Noa Reis, Thorsten Hoppe, Michael H. Glickman
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714003325

Internet

http://www.sciencedirect.com/science/article/pii/S2211124714003325

Similar Items