AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice

AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice

Abstract Renal tubulointerstitial fibrosis was a crucial pathological feature of diabetic nephropathy (DN), and renal tubular injury might associate with abnormal mitophagy. In this study, we investigated the effects and molecular mechanisms of AMPK agonist metformin on mitophagy and cellular injury...

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Bibliographic Details
Main Authors: Ya-chun Han, Shi-qi Tang, Yu-ting Liu, Ai-mei Li, Ming Zhan, Ming Yang, Na Song, Wei Zhang, Xue-qin Wu, Can-hui Peng, Hao Zhang, Shikun Yang
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04184-8

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https://doi.org/10.1038/s41419-021-04184-8

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