Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity

Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity

Heart failure (HF) is an important and leading cause of substantial morbidity and mortality globally. The angiotensin-converting enzymatic (ACE) is the causative source for congestive heart failure. Natural products and its derivatives play a vital role in drug discovery and development owing to the...

Full description

Bibliographic Details
Main Authors: Junli Liu, Yunhe Liu, Hui Yu, Ying Zhang, Alan Chen-Yu Hsu, Mingming Zhang, Yawei Gou, Wei Sun, Fang Wang, Pingya Li, Jinping Liu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pyxinol
Fatty acid esters
ACE inhibition
Molecular docking
Heart failure
Metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220312427

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220312427

Similar Items