Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA

Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA

Loss of immune checkpoint (IC) Programmed Death-1 (PD-1) and PD-Ligand1 (PD-L1) expression has been implicated in the immunopathology of Giant Cell Arteritis (GCA). The contribution of the negative immune checkpoint V-domain Immunoglobulin-containing suppressor of T cell activation (VISTA) to GCA pa...

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Bibliographic Details
Main Authors: Rebeca Hid Cadena, Rosanne D. Reitsema, Minke G. Huitema, Yannick van Sleen, Kornelis S. M. van der Geest, Peter Heeringa, Annemieke M. H. Boots, Wayel H. Abdulahad, Elisabeth Brouwer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
immune checkpoints
V-domain immunoglobulin-containing suppressor of T cell activation (VISTA)
programmed death-1 (PD-1)
vasculitis
giant cell arteritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01638/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01638/full

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