Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway

Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway

Oxidative stress-induced neuronal cell damage is a crucial factor in the pathogenesis of mitochondria-associated neurological diseases. Therefore, elimination of overproduction of mitochondrial reactive oxygen species (mtROS) may be a potential strategy for prevention and treatment of neurological d...

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Bibliographic Details
Main Authors: Jianmei Gao, Shuang Liu, Fan Xu, Yuangui Liu, Chun Lv, Yan Deng, Jingshan Shi, Qihai Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
trilobatin
hydrogen peroxide
PC12 cells
AMPK
Nrf2
Sirt3
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00267/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00267/full

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