A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

Immune checkpoint blockade (ICB) expands the therapeutic options for metastatic lung cancer nowadays representing a standard frontline strategy as monotherapy or combination therapy, as well as an option in oncogene-addicted NSCLC after exhaustion of targeted therapies. Predictive markers are urgent...

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Bibliographic Details
Main Authors: Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Stefan Fröhling, Solange Peters, Barbara Seliger, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
lung adenocarcinoma
immune checkpoint blockade
mrna expression
b cells
tumor-infiltrating lymphocytes
response prediction
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1860586

Internet

http://dx.doi.org/10.1080/2162402X.2020.1860586

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