Toxoplasma gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia vs. Control Subjects

Toxoplasma gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia vs. Control Subjects

Background: Chronic infection with Toxoplasma gondii (TOXO) results in microcysts in the brain that are controlled by inflammatory activation and subsequent changes in the kynurenine pathway. TOXO seropositivity is associated with a heightened risk of schizophrenia (SCZ) and with cognitive impairmen...

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Bibliographic Details
Main Authors: Bradley D. Pearce, Nicholas Massa, David R. Goldsmith, Zeal H. Gandhi, Allison Hankus, Alaaeddin Alrohaibani, Neha Goel, Bruce Cuthbert, Molly Fargotstein, Dana Boyd Barr, Parinya Panuwet, Victoria M. Brown, Erica Duncan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Psychiatry
Subjects:
schizophrenia
acoustic startle
Toxoplasma gondii
kynurenines
startle latency
tryptophan
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2020.552743/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2020.552743/full

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