Escherichia coli Nissle 1917 administered as a dextranomar microsphere biofilm enhances immune responses against human rotavirus in a neonatal malnourished pig model colonized with human infant fecal microbiota.

Escherichia coli Nissle 1917 administered as a dextranomar microsphere biofilm enhances immune responses against human rotavirus in a neonatal malnourished pig model colonized with human infant fecal microbiota.

Human rotavirus (HRV) is a leading cause of diarrhea in children. It causes significant morbidity and mortality, especially in low- and middle-income countries (LMICs), where HRV vaccine efficacy is low. The probiotic Escherichia coli Nissle (EcN) 1917 has been widely used in the treatment of enteri...

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Bibliographic Details
Main Authors: Husheem Michael, Francine C Paim, Ayako Miyazaki, Stephanie N Langel, David D Fischer, Juliet Chepngeno, Steven D Goodman, Gireesh Rajashekara, Linda J Saif, Anastasia Nickolaevna Vlasova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0246193

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https://doi.org/10.1371/journal.pone.0246193

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