Discovery of a novel (R)-selective bacterial hydroxynitrile lyase from Acidobacterium capsulatum

Discovery of a novel (R)-selective bacterial hydroxynitrile lyase from Acidobacterium capsulatum

Hydroxynitrile lyases (HNLs) are powerful carbon–carbon bond forming enzymes. The reverse of their natural reaction – the stereoselective addition of hydrogen cyanide (HCN) to carbonyls – yields chiral cyanohydrins, versatile building blocks for the pharmaceutical and chemical industry. Recently, ba...

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Bibliographic Details
Main Authors: Romana Wiedner, Mandana Gruber-Khadjawi, Helmut Schwab, Kerstin Steiner
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Hydroxynitrile lyase
Manganese-dependent HNL
Biocatalysis
Cyanohydrin synthesis
Mandelonitrile
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014000117

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http://www.sciencedirect.com/science/article/pii/S2001037014000117

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