Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics

Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics

Bone-forming cells build mineralized microstructure and couple with bone-resorbing cells, harmonizing bone mineral acquisition, and remodeling to maintain bone mass homeostasis. Mitochondrial glycolysis and oxidative phosphorylation pathways together with ROS generation meet the energy requirement f...

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Bibliographic Details
Main Authors: Feng-Sheng Wang, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, Wei-Shiung Lian
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
osteoblasts
osteoporosis
biophysical stimulation
mechanosensitive
mitochondria biogenesis
PGC-1α
Online Access:https://www.mdpi.com/2076-3921/10/9/1394

Internet

https://www.mdpi.com/2076-3921/10/9/1394

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