Cycling hypoxia selects for constitutive HIF stabilization

Cycling hypoxia selects for constitutive HIF stabilization

Abstract Tumors experience temporal and spatial fluctuations in oxygenation. Hypoxia inducible transcription factors (HIF-α) respond to low levels of oxygen and induce re-supply oxygen. HIF-α stabilization is typically facultative, induced by hypoxia and reduced by normoxia. In some cancers, HIF-α s...

Full description

Bibliographic Details
Main Authors: Mariyah Pressley, Jill A. Gallaher, Joel S. Brown, Michal R. Tomaszewski, Punit Borad, Mehdi Damaghi, Robert J. Gillies, Christopher J. Whelan
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85184-8

Internet

https://doi.org/10.1038/s41598-021-85184-8

Similar Items