A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to...

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Bibliographic Details
Main Authors:	Longfei Mao, Averina Nicolae, Miguel A.P. Oliveira, Feng He, Siham Hachi, Ronan M.T. Fleming
Format:	Article
Language:	English
Published:	Elsevier 2015-01-01
Series:	Computational and Structural Biotechnology Journal
Subjects:	Dopaminergic neurons Constraint-based modelling Metabolic reconstruction Energy metabolism Parkinson's disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037015000379

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