A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to...

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Main Authors:	Longfei Mao, Averina Nicolae, Miguel A.P. Oliveira, Feng He, Siham Hachi, Ronan M.T. Fleming
Format:	Article
Language:	English
Published:	Elsevier 2015-01-01
Series:	Computational and Structural Biotechnology Journal
Subjects:	Dopaminergic neurons Constraint-based modelling Metabolic reconstruction Energy metabolism Parkinson's disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037015000379

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spelling	doaj-80f6f0fc2cc045cbbfd1488d0bc05c292020-11-24T22:10:09ZengElsevierComputational and Structural Biotechnology Journal2001-03702015-01-0113C48449110.1016/j.csbj.2015.08.002A constraint-based modelling approach to metabolic dysfunction in Parkinson's diseaseLongfei Mao0Averina Nicolae1Miguel A.P. Oliveira2Feng He3Siham Hachi4Ronan M.T. Fleming5Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, L-4362 Esch-Belval, LuxembourgLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, L-4362 Esch-Belval, LuxembourgLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, L-4362 Esch-Belval, LuxembourgLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, L-4362 Esch-Belval, LuxembourgLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, L-4362 Esch-Belval, LuxembourgLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, L-4362 Esch-Belval, LuxembourgOne of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.http://www.sciencedirect.com/science/article/pii/S2001037015000379Dopaminergic neuronsConstraint-based modellingMetabolic reconstructionEnergy metabolismParkinson's disease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Longfei Mao Averina Nicolae Miguel A.P. Oliveira Feng He Siham Hachi Ronan M.T. Fleming
spellingShingle	Longfei Mao Averina Nicolae Miguel A.P. Oliveira Feng He Siham Hachi Ronan M.T. Fleming A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease Computational and Structural Biotechnology Journal Dopaminergic neurons Constraint-based modelling Metabolic reconstruction Energy metabolism Parkinson's disease
author_facet	Longfei Mao Averina Nicolae Miguel A.P. Oliveira Feng He Siham Hachi Ronan M.T. Fleming
author_sort	Longfei Mao
title	A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_short	A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_full	A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_fullStr	A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_full_unstemmed	A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease
title_sort	constraint-based modelling approach to metabolic dysfunction in parkinson's disease
publisher	Elsevier
series	Computational and Structural Biotechnology Journal
issn	2001-0370
publishDate	2015-01-01
description	One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.
topic	Dopaminergic neurons Constraint-based modelling Metabolic reconstruction Energy metabolism Parkinson's disease
url	http://www.sciencedirect.com/science/article/pii/S2001037015000379
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A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

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