SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models

SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models

Abstract Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory environments in disease contexts and thereby contribute to the progression of neuronal loss in neurodegenerative disorders. Correcting the diseased properties of glia is therefore an appealing strategy...

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Bibliographic Details
Main Authors: Oh‐Chan Kwon, Jae‐Jin Song, Yunseon Yang, Seong‐Hoon Kim, Ji Young Kim, Min‐Jong Seok, Inhwa Hwang, Je‐Wook Yu, Jenisha Karmacharya, Han‐Joo Maeng, Jiyoung Kim, Eek‐hoon Jho, Seung Yeon Ko, Hyeon Son, Mi‐Yoon Chang, Sang‐Hun Lee
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:EMBO Molecular Medicine
Subjects:
glia
neuroinflammation
Parkinson’s disease
serum/glucocorticoid related kinase 1
synuclein alpha
Online Access:https://doi.org/10.15252/emmm.202013076

Internet

https://doi.org/10.15252/emmm.202013076

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