Impaired Replication Timing Promotes Tissue-Specific Expression of Common Fragile Sites

Impaired Replication Timing Promotes Tissue-Specific Expression of Common Fragile Sites

Common fragile sites (CFSs) are particularly vulnerable regions of the genome that become visible as breaks, gaps, or constrictions on metaphase chromosomes when cells are under replicative stress. Impairment in DNA replication, late replication timing, enrichment of A/T nucleotides that tend to for...

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Bibliographic Details
Main Authors: Klizia Maccaroni, Elisa Balzano, Federica Mirimao, Simona Giunta, Franca Pelliccia
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Genes
Subjects:
common fragile sites
dna replication timing
replicative stress
tissue specificity
human fetal fibroblasts
chromosomal instability
fluorescent in situ hybridization
gene length
long genes
Online Access:https://www.mdpi.com/2073-4425/11/3/326

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https://www.mdpi.com/2073-4425/11/3/326

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