A density-based approach for detecting complexes in weighted PPI networks by semantic similarity.

Protein complex detection in PPI networks plays an important role in analyzing biological processes. A new algorithm-DBGPWN-is proposed for predicting complexes in PPI networks. Firstly, a method based on gene ontology is used to measure semantic similarities between interacted proteins, and the sim...

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Bibliographic Details
Main Authors: HongFang Zhou, Jie Liu, JunHuai Li, WenCong Duan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5507511?pdf=render