CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?

CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?

Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs. Therefore, genetic variation in CYP3A4 could potentially affect the pharmacokinetics, toxicity and clinical outcome of drug treat...

Full description

Bibliographic Details
Main Authors: Tessa A. M. Mulder, Ruben A. G. van Eerden, Mirjam de With, Laure Elens, Dennis A. Hesselink, Maja Matic, Sander Bins, Ron H. J. Mathijssen, Ron H. N. van Schaik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
cytochrome P450
CYP3A4
CYP3A4∗22
genotyping
genotype-guided dosing
rs35599367
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.711943/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.711943/full

Similar Items