A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

Glutamate-induced excitotoxicity is one of the main causes of neuronal cell death in stroke. Compound 22a has been previously reported as a promising neuroprotective compound derived from tetramethylpyrazine, which is a widely used active ingredient of traditional Chinese medicine Chuanxiong (Ligust...

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Bibliographic Details
Main Authors: Haiyun Chen, Jie Cao, Zeyu Zhu, Gaoxiao Zhang, Luchen Shan, Pei Yu, Yuqiang Wang, Yewei Sun, Zaijun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
ischemic stroke
tetramethylpyrazine derivative 22a
excitotoxicity
neuroprotection
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00567/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00567/full

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