Asymmetric Total Syntheses of Two 3-Acyl-5,6- dihydro-2H-pyrones: (R)-Podoblastin-S and (R)- Lachnelluloic Acid with Verification of the Absolute Configuration of (−)-Lachnelluloic Acid

Asymmetric Total Syntheses of Two 3-Acyl-5,6- dihydro-2H-pyrones: (R)-Podoblastin-S and (R)- Lachnelluloic Acid with Verification of the Absolute Configuration of (−)-Lachnelluloic Acid

Expedient asymmetric total syntheses of both (R)-podoblastin-S and (R)-lachnelluloic acid, representative of natural 3-acyl-5,6-dihydro-2H-pyran-2-ones, were performed. Compared with the reported total synthesis of (R)-podoblastin-S (14 steps, overall 5% yield), the present study was achieved in onl...

Full description

Bibliographic Details
Main Authors: Tetsuya Fujiwara, Takeshi Tsutsumi, Kohei Nakata, Hidefumi Nakatsuji, Yoo Tanabe
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
asymmetric Mukaiyama aldol reaction
asymmetric total synthesis
natural fungicide
3- acyl-5,6-dihydro-2H-pyrones
1,3-bis(trimethylsiloxy)diene
podoblastin
lachnelluloic acid
alternaric acid
Online Access:http://www.mdpi.com/1420-3049/22/1/69

Internet

http://www.mdpi.com/1420-3049/22/1/69

Similar Items