Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3
In most mammals, imprinted genes contain epigenetic marks that differ in each parental genome and control their parent-of-origin-specific expression. Here, the authors map imprinted genes in mouse preimplantation embryos and find that imprinted gene expression in blastocysts is mainly dependent on P...
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Nature Publishing Group
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23510-4 |
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doaj-80a4a9c1e8f242dab49a92d2bed3b3ac2021-06-27T11:12:28ZengNature Publishing GroupNature Communications2041-17232021-06-0112111610.1038/s41467-021-23510-4Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3Laura Santini0Florian Halbritter1Fabian Titz-Teixeira2Toru Suzuki3Maki Asami4Xiaoyan Ma5Julia Ramesmayer6Andreas Lackner7Nick Warr8Florian Pauler9Simon Hippenmeyer10Ernest Laue11Matthias Farlik12Christoph Bock13Andreas Beyer14Anthony C. F. Perry15Martin Leeb16Max Perutz Laboratories Vienna, University of Vienna, Vienna BiocenterSt. Anna Children’s Cancer Research Institute (CCRI)Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of CologneLaboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of BathLaboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of BathDepartment of Biochemistry, University of CambridgeMax Perutz Laboratories Vienna, University of Vienna, Vienna BiocenterMax Perutz Laboratories Vienna, University of Vienna, Vienna BiocenterMammalian Genetics Unit, MRC Harwell InstituteInstitute for Science and Technology AustriaInstitute for Science and Technology AustriaDepartment of Biochemistry, University of CambridgeCeMM Research Center for Molecular Medicine of the Austrian Academy of SciencesCeMM Research Center for Molecular Medicine of the Austrian Academy of SciencesCologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of CologneLaboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of BathMax Perutz Laboratories Vienna, University of Vienna, Vienna BiocenterIn most mammals, imprinted genes contain epigenetic marks that differ in each parental genome and control their parent-of-origin-specific expression. Here, the authors map imprinted genes in mouse preimplantation embryos and find that imprinted gene expression in blastocysts is mainly dependent on Polycomb-mediated H3K27me3-associated gene silencing.https://doi.org/10.1038/s41467-021-23510-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Laura Santini Florian Halbritter Fabian Titz-Teixeira Toru Suzuki Maki Asami Xiaoyan Ma Julia Ramesmayer Andreas Lackner Nick Warr Florian Pauler Simon Hippenmeyer Ernest Laue Matthias Farlik Christoph Bock Andreas Beyer Anthony C. F. Perry Martin Leeb |
| spellingShingle |
Laura Santini Florian Halbritter Fabian Titz-Teixeira Toru Suzuki Maki Asami Xiaoyan Ma Julia Ramesmayer Andreas Lackner Nick Warr Florian Pauler Simon Hippenmeyer Ernest Laue Matthias Farlik Christoph Bock Andreas Beyer Anthony C. F. Perry Martin Leeb Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3 Nature Communications |
| author_facet |
Laura Santini Florian Halbritter Fabian Titz-Teixeira Toru Suzuki Maki Asami Xiaoyan Ma Julia Ramesmayer Andreas Lackner Nick Warr Florian Pauler Simon Hippenmeyer Ernest Laue Matthias Farlik Christoph Bock Andreas Beyer Anthony C. F. Perry Martin Leeb |
| author_sort |
Laura Santini |
| title |
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3 |
| title_short |
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3 |
| title_full |
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3 |
| title_fullStr |
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3 |
| title_full_unstemmed |
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3 |
| title_sort |
genomic imprinting in mouse blastocysts is predominantly associated with h3k27me3 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-06-01 |
| description |
In most mammals, imprinted genes contain epigenetic marks that differ in each parental genome and control their parent-of-origin-specific expression. Here, the authors map imprinted genes in mouse preimplantation embryos and find that imprinted gene expression in blastocysts is mainly dependent on Polycomb-mediated H3K27me3-associated gene silencing. |
| url |
https://doi.org/10.1038/s41467-021-23510-4 |
| work_keys_str_mv |
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