Optimization of Forced Degradation Using Experimental Design and Development of a Stability-Indicating Liquid Chromatographic Assay Method for Rebamipide in Bulk and Tablet Dosage Form

Optimization of Forced Degradation Using Experimental Design and Development of a Stability-Indicating Liquid Chromatographic Assay Method for Rebamipide in Bulk and Tablet Dosage Form

A novel stability-indicating RP-HPLC assay method was developed and validated for quantitative determination of rebamipide in bulk and tablet dosage form. Rebamipide (drug and drug product) solutions were exposed to acid and alkali hydrolysis, thermal stress, oxidation by hydrogen peroxide and photo...

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Bibliographic Details
Main Authors: Sandeep SONAWANE, Paraag GIDE
Format: Article
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2016-09-01
Series:Scientia Pharmaceutica
Subjects:
Experimental design
Rebamipide
Validation
Stability-indicating
Microwave energy
RP-HPLC
Degradation product
Online Access:http://www.mdpi.com/2218-0532/79/1/85

Internet

http://www.mdpi.com/2218-0532/79/1/85

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