Anticancer Applications of Nanostructured Silica-Based Materials Functionalized with Titanocene Derivatives: Induction of Cell Death Mechanism through TNFR1 Modulation

Anticancer Applications of Nanostructured Silica-Based Materials Functionalized with Titanocene Derivatives: Induction of Cell Death Mechanism through TNFR1 Modulation

A series of cytotoxic titanocene derivatives have been immobilized onto nanostructured silica-based materials using two different synthetic routes, namely, (i) a simple grafting protocol via protonolysis of the Ti–Cl bond; and (ii) a tethering method by elimination of ethanol using triethoxysilyl mo...

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Bibliographic Details
Main Authors: Santiago Gómez-Ruiz, Alberto García-Peñas, Sanjiv Prashar, Antonio Rodríguez-Diéguez, Eva Fischer-Fodor
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Materials
Subjects:
nanostructured silica
titanocene
cytotoxicity
anticancer
tumor necrosis factor
TNFR1 modulation
Online Access:http://www.mdpi.com/1996-1944/11/2/224

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http://www.mdpi.com/1996-1944/11/2/224

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