Sirtuins In Neurodegenerative Diseases: An Update On Potential Mechanisms

Sirtuins In Neurodegenerative Diseases: An Update On Potential Mechanisms

Silent information regulator 2 proteins (sirtuins or SIRTs) are a group of deacetylases (or deacylases) whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD+). Compelling evidence supports that sirtuins play major roles in many aspects of physiology, especially i...

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Bibliographic Details
Main Authors: Sang-won eMin, Peter Dongmin Sohn, Seo-hyun eCho, Raymond A Swanson, Li eGan
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Inflammation
Mitochondria
neurodegeneration
SIRT1
NF-κB
tau
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00053/full
Description
Summary:Silent information regulator 2 proteins (sirtuins or SIRTs) are a group of deacetylases (or deacylases) whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD+). Compelling evidence supports that sirtuins play major roles in many aspects of physiology, especially in pathways related to aging–the predominant and unifying risk factor for neurodegenerative diseases. The focus of this review is to examine the molecular mechanisms underlying the protective effects of sirtuins in neurodegenerative diseases, focusing on protein homeostasis, neural plasticity, mitochondrial function, and sustained chronic inflammation. We will also examine the potential and challenges of targeting sirtuin pathways to block these pathogenic pathways.
ISSN:1663-4365

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