Sirtuins In Neurodegenerative Diseases: An Update On Potential Mechanisms

Sirtuins In Neurodegenerative Diseases: An Update On Potential Mechanisms

Silent information regulator 2 proteins (sirtuins or SIRTs) are a group of deacetylases (or deacylases) whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD+). Compelling evidence supports that sirtuins play major roles in many aspects of physiology, especially i...

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Bibliographic Details
Main Authors: Sang-won eMin, Peter Dongmin Sohn, Seo-hyun eCho, Raymond A Swanson, Li eGan
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Inflammation
Mitochondria
neurodegeneration
SIRT1
NF-κB
tau
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00053/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00053/full

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