SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway

Abstract Background Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs). Our previous study on dental tissue-derived MSCs demonstrated that secreted frizzled-related protein 2 (SFRP2), a Wnt in...

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Bibliographic Details
Main Authors: Luyuan Jin, Yu Cao, Guoxia Yu, Jinsong Wang, Xiao Lin, Lihua Ge, Juan Du, Liping Wang, Shu Diao, Xiaomeng Lian, Songlin Wang, Rui Dong, Zhaochen Shan
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
SFRP2
Osteogenic differentiation
Stem cells from apical papilla (SCAPs)
Wnt signaling
β-catenin
Online Access:http://link.springer.com/article/10.1186/s11658-017-0044-2

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http://link.springer.com/article/10.1186/s11658-017-0044-2

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