Diversity in lac Operon Regulation among Diverse Escherichia coli Isolates Depends on the Broader Genetic Background but Is Not Explained by Genetic Relatedness

The lac operon of Escherichia coli is a classic model for studying gene regulation. This study has uncovered features such as the environmental input logic controlling gene expression, as well as gene expression bistability and hysteresis. Most lac operon studies have focused on a few lab strains, a...

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Bibliographic Details
Main Authors: Kelly N. Phillips, Scott Widmann, Huei-Yi Lai, Jennifer Nguyen, J. Christian J. Ray, Gábor Balázsi, Tim F. Cooper
Format: Article
Language:English
Published: American Society for Microbiology 2019-11-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.02232-19