TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.

TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.

Aberrant DNA methylation is commonly observed in colorectal cancer (CRC), but the underlying mechanism is not fully understood. 5-hydroxymethylcytosine levels and TET1 expression are both reduced in CRC, while epigenetic silencing of TET1 is reportedly associated with the CpG island methylator pheno...

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Bibliographic Details
Main Authors: Masahiro Kai, Takeshi Niinuma, Hiroshi Kitajima, Eiichiro Yamamoto, Taku Harada, Hironori Aoki, Reo Maruyama, Mutsumi Toyota, Yasushi Sasaki, Tamotsu Sugai, Takashi Tokino, Hiroshi Nakase, Hiromu Suzuki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5158030?pdf=render

Internet

http://europepmc.org/articles/PMC5158030?pdf=render

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