Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats

Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats

Abstract Background Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane–prostaglandin (TP) receptors, causing vasoconstriction and inflammation. Here, we evaluated terutrob...

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Bibliographic Details
Main Authors: David Lagier, David Tonon, Philippe Garrigue, Benjamin Guillet, Laura Giacomino, Jean-Charles Martin, Marie-Christine Alessi, Nicolas Bruder, Lionel J. Velly
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Critical Care
Subjects:
Subarachnoid haemorrhage
Single-photon emission computerized tomography
Thromboxane–prostaglandin receptor
Cerebral vasospasm
Blood brain barrier
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13054-019-2338-4

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http://link.springer.com/article/10.1186/s13054-019-2338-4

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