Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.

Bibliographic Details
Main Authors: Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23615-w

Internet

https://doi.org/10.1038/s41467-021-23615-w

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