Bordetella pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice

Bordetella pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice

Hematopoietic stem and progenitor cell (HSPC) compartments are altered to direct immune responses to infection. Their roles during immunization are not well-described. To elucidate mechanisms for waning immunity following immunization with acellular vaccines (ACVs) against Bordetella pertussis (Bp),...

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Bibliographic Details
Main Authors: Melinda E. Varney, Dylan T. Boehm, Katherine DeRoos, Evan S. Nowak, Ting Y. Wong, Emel Sen-Kilic, Shebly D. Bradford, Cody Elkins, Matthew S. Epperly, William T. Witt, Mariette Barbier, F. Heath Damron
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
vaccination
Bordetella pertussis
respiratory pathogen
hematopoietic stem cell
immunobiology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02376/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02376/full

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