Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma

Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma

Abstract Background We previously reported early on-treatment significant modulation in circulating regulatory T cell (Treg), myeloid derived suppressor cells (MDSC) and antigen-specific type I CD4+ and CD8+ T cells that correlated with clinical outcome in regionally advanced melanoma patients treat...

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Bibliographic Details
Main Authors: Janet Retseck, Alexis Nasr, Yan Lin, Huang Lin, Prateek Mendiratta, Lisa H. Butterfield, Ahmad A. Tarhini
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Translational Medicine
Subjects:
Melanoma
CTLA4
Ipilimumab
Regulatory T cells
MDSC
Tumor antigens
Online Access:http://link.springer.com/article/10.1186/s12967-018-1563-y

Internet

http://link.springer.com/article/10.1186/s12967-018-1563-y

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