Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus

Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus

Lassa virus (LASV) causes a viral haemorrhagic fever in humans and is a major public health concern in West Africa. An efficient immune response to LASV appears to rely on type I interferon (IFN-I) production and T-cell activation. We evaluated the response of plasmacytoid dendritic cells (pDC) to L...

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Main Authors: Justine Schaeffer, Stéphanie Reynard, Xavier Carnec, Natalia Pietrosemoli, Marie-Agnès Dillies, Sylvain Baize
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Viruses
Subjects:
Lassa virus
Mopeia virus
viral haemorrhagic fever
plasmacytoid dendritic cells
type I interferon
Online Access:https://www.mdpi.com/1999-4915/11/3/287
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spelling doaj-801bd0bfddfe4d18988332ea3b8d008d2020-11-25T00:50:03ZengMDPI AGViruses1999-49152019-03-0111328710.3390/v11030287v11030287Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa VirusJustine Schaeffer0Stéphanie Reynard1Xavier Carnec2Natalia Pietrosemoli3Marie-Agnès Dillies4Sylvain Baize5Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, FranceUnité de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, FranceUnité de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, FranceHub de Bioinformatique et Biostatistique–C3BI, Institut Pasteur, USR 3756 CNRS, 75015 Paris, FranceHub de Bioinformatique et Biostatistique–C3BI, Institut Pasteur, USR 3756 CNRS, 75015 Paris, FranceUnité de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, FranceLassa virus (LASV) causes a viral haemorrhagic fever in humans and is a major public health concern in West Africa. An efficient immune response to LASV appears to rely on type I interferon (IFN-I) production and T-cell activation. We evaluated the response of plasmacytoid dendritic cells (pDC) to LASV, as they are an important and early source of IFN-I. We compared the response of primary human pDCs to LASV and Mopeia virus (MOPV), which is very closely related to LASV, but non-pathogenic. We showed that pDCs are not productively infected by either MOPV or LASV, but produce IFN-I. However, the activation of pDCs was more robust in response to MOPV than LASV. In vivo, pDC activation may support the control of viral replication through IFN-I production, but also improve the induction of a global immune response. Therefore, pDC activation could play a role in the control of LASV infection.https://www.mdpi.com/1999-4915/11/3/287Lassa virusMopeia virusviral haemorrhagic feverplasmacytoid dendritic cellstype I interferon
collection DOAJ
language English
format Article
sources DOAJ
author Justine Schaeffer
Stéphanie Reynard
Xavier Carnec
Natalia Pietrosemoli
Marie-Agnès Dillies
Sylvain Baize
spellingShingle Justine Schaeffer
Stéphanie Reynard
Xavier Carnec
Natalia Pietrosemoli
Marie-Agnès Dillies
Sylvain Baize
Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus
Viruses
Lassa virus
Mopeia virus
viral haemorrhagic fever
plasmacytoid dendritic cells
type I interferon
author_facet Justine Schaeffer
Stéphanie Reynard
Xavier Carnec
Natalia Pietrosemoli
Marie-Agnès Dillies
Sylvain Baize
author_sort Justine Schaeffer
title Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus
title_short Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus
title_full Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus
title_fullStr Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus
title_full_unstemmed Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus
title_sort non-pathogenic mopeia virus induces more robust activation of plasmacytoid dendritic cells than lassa virus
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2019-03-01
description Lassa virus (LASV) causes a viral haemorrhagic fever in humans and is a major public health concern in West Africa. An efficient immune response to LASV appears to rely on type I interferon (IFN-I) production and T-cell activation. We evaluated the response of plasmacytoid dendritic cells (pDC) to LASV, as they are an important and early source of IFN-I. We compared the response of primary human pDCs to LASV and Mopeia virus (MOPV), which is very closely related to LASV, but non-pathogenic. We showed that pDCs are not productively infected by either MOPV or LASV, but produce IFN-I. However, the activation of pDCs was more robust in response to MOPV than LASV. In vivo, pDC activation may support the control of viral replication through IFN-I production, but also improve the induction of a global immune response. Therefore, pDC activation could play a role in the control of LASV infection.
topic Lassa virus
Mopeia virus
viral haemorrhagic fever
plasmacytoid dendritic cells
type I interferon
url https://www.mdpi.com/1999-4915/11/3/287
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AT xaviercarnec nonpathogenicmopeiavirusinducesmorerobustactivationofplasmacytoiddendriticcellsthanlassavirus
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