Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction.
Cellular signaling networks are subject to transcriptional and proteolytic regulation under both physiological and pathological conditions. For example, the expression of proteins subject to covalent modification by phosphorylation is known to be altered upon cellular differentiation or during carci...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-10-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://dx.doi.org/10.1371/journal.pcbi.0010054 |