Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia

Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia

Debilitating anemias in chronic diseases can result from deficient iron delivery to red cell precursors. Here, the authors show how this deficiency damages the cytoskeletal framework of progenitor cells and identify a targeted strategy for cytoskeletal repair, leading to anemia correction.

Bibliographic Details
Main Authors: Adam N. Goldfarb, Katie C. Freeman, Ranjit K. Sahu, Kamaleldin E. Elagib, Maja Holy, Abhinav Arneja, Renata Polanowska-Grabowska, Alejandro A. Gru, Zollie White, Shadi Khalil, Michael J. Kerins, Aikseng Ooi, Norbert Leitinger, Chance John Luckey, Lorrie L. Delehanty
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21938-2

Internet

https://doi.org/10.1038/s41467-021-21938-2

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