The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus

The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus

ObjectivesStaphylococcus aureus Smith strain is a historical strain widely used for research purposes in animal infection models for testing the therapeutic activity of antimicrobial agents. We found that it displayed higher sensitivity toward lysocin E, a menaquinone (MK) targeting antibiotic, comp...

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Bibliographic Details
Main Authors: Suresh Panthee, Atmika Paudel, Hiroshi Hamamoto, Anne-Catrin Uhlemann, Kazuhisa Sekimizu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
menaquinone
Staphylococcus aureus
MRSA
mechanisms of action
HPLC
genomics
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.02076/full

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https://www.frontiersin.org/article/10.3389/fmicb.2020.02076/full

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