HOTAIR Accelerates Dyskinesia in a MPTP-Lesioned Mouse Model of PD via SSTR1 Methylation-Mediated ERK1/2 Axis

HOTAIR Accelerates Dyskinesia in a MPTP-Lesioned Mouse Model of PD via SSTR1 Methylation-Mediated ERK1/2 Axis

Homeobox transcript antisense RNA (HOTAIR), has been associated with neuroprotective effects in Parkinson’s disease (PD). However, the underlying mechanisms still remain unclear. Hence, this present study attempted to clarify the functional relevance of HOTAIR in PD. We established an in vivo mouse...

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Bibliographic Details
Main Authors: Lijun Cai, Li Tu, Xiulin Yang, Qian Zhang, Tian Tian, Rang Gu, Xiang Qu, Qian Wang, Jinyong Tian
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
HOTAIR
dyskinesia
Parkinson’s disease
SSTR1
ERK1/2 axis
methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302080

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http://www.sciencedirect.com/science/article/pii/S2162253120302080

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