Inhibition of janus kinase 2 by compound AG490 suppresses the proliferation of MDA-MB-231 cells via up-regulating SARI (suppressor of AP-1, regulated by IFN)

Inhibition of janus kinase 2 by compound AG490 suppresses the proliferation of MDA-MB-231 cells via up-regulating SARI (suppressor of AP-1, regulated by IFN)

Objective(s): The Janus kinase-signal transducers and activators of transcription signaling pathway (JAK/STAT pathway) play an important role in proliferation of breast cancer cells. Previous data showed that inhibition of STAT3 suppresses the growth of breast cancer cells, but the associated mechan...

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Bibliographic Details
Main Authors: Yan-xia Zhang, Li Yan, Guang-yu Liu, Wen-jun Chen, Wei-hong Gong, Jin-ming Yu
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2015-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
AG490
MDA-MB-231
Proliferation
SARI
STAT3
Online Access:http://ijbms.mums.ac.ir/pdf_4538_6cc688808d43b89eddc0bd5b731393bf.html

Internet

http://ijbms.mums.ac.ir/pdf_4538_6cc688808d43b89eddc0bd5b731393bf.html

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