Modeling the Effect of Temperature on Membrane Response of Light Stimulation in Optogenetically-Targeted Neurons

Optogenetics is revolutionizing Neuroscience, but an often neglected effect of light stimulation of the brain is the generation of heat. In extreme cases, light-generated heat kills neurons, but mild temperature changes alter neuronal function. To date, most in vivo experiments rely on light stimula...

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Bibliographic Details
Main Authors: Helton M. Peixoto, Rossana M. S. Cruz, Thiago C. Moulin, Richardson N. Leão
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Computational Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fncom.2020.00005/full