Vaccination with Prion Peptide-Displaying Polyomavirus-Like Particles Prolongs Incubation Time in Scrapie-Infected Mice

Vaccination with Prion Peptide-Displaying Polyomavirus-Like Particles Prolongs Incubation Time in Scrapie-Infected Mice

Prion diseases like scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle or Creutzfeldt–Jakob disease (CJD) in humans are fatal neurodegenerative diseases characterized by the conformational conversion of the normal, mainly α-helical cellular prion protein (PrP<sup>C</sup>)...

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Bibliographic Details
Main Authors: Martin Eiden, Alma Gedvilaite, Fabienne Leidel, Rainer G. Ulrich, Martin H. Groschup
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
prion disease
polyomavirus
virus-like particles
active immunisation
Online Access:https://www.mdpi.com/1999-4915/13/5/811

Internet

https://www.mdpi.com/1999-4915/13/5/811

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