CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller

CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller

<p>Abstract</p> <p>Background</p> <p>Virus-specific T cells are critical components in the containment of immunodeficiency virus infections. While the protective role of CD8+ T cells is well established by studies of CD8+ T cell-mediated viral escape, it remains unknown...

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Bibliographic Details
Main Authors: Burwitz Benjamin J, Giraldo-Vela Juan, Reed Jason, Newman Laura P, Bean Alexander T, Nimityongskul Francesca A, Castrovinci Philip A, Maness Nicholas J, Leon Enrique J, Rudersdorf Richard, Sacha Jonah B
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Retrovirology
Subjects:
HIV
Cytolytic CD4+ T cells
Immune evasion
Online Access:http://www.retrovirology.com/content/9/1/91

Internet

http://www.retrovirology.com/content/9/1/91

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