Immunological response as a source to variability in drug metabolism and transport

Through the last decades it has become increasingly evident that disease-states involving cytokines affect the pharmacokinetics of drugs through regulation of expression and activity of drug-metabolizing enzymes, and more recently also drug transporters. The clinical implication is however difficult...

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Bibliographic Details
Main Authors: Hege eChristensen, Monica eHermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00008/full